Preheat oven to 350F. Place bread cubes in a 15x10x1-inch baking pan. Bake, uncovered, in the preheated oven for 10 minutes, stirring once.

Spread half of the bread cubes in a greased 2-quart square baking dish. Top with half of the pepperoni, half of the pepperoncini peppers, all of the spinach, and all of the tomatoes. Sprinkle with 1/2 cup of the Italian-blend cheeses. Repeat layers with remaining bread, pepperoni, pepperoncini peppers, and Italian-blend cheese.

Whisk together eggs, milk, Italian seasoning, cayenne pepper, and 1/4 teaspoon salt; pour evenly over layers in dish. Press bread cubes down with a wooden spoon. Sprinkle with Parmesan cheese. Cover and chill for 2 to 24 hours.

Preheat oven to 350F. Bake, uncovered, in the preheated oven for 35 to 45 minutes or until the internal temperature registers 170F on an instant-read thermometer. Let stand for 10 minutes before serving. Makes 6 servings.

Spicy Mexican Strata: Prepare as above, except substitute 4 ounces chorizo sausage, cooked and crumbled, for pepperoni; one 4.5-ounce can diced green chile peppers, drained, for pepperoncini peppers; and Mexican-blend cheese for Italian-blend cheese. Omit Italian seasoning. Substitute crumbled queso fresco or additional Mexican-blend cheese for Parmesan cheese.